HIV/AIDS Dementia

Monocyte chemoattractant protein-1 protects brain cells from Tat-induced toxicity

Published in AIDS Weekly, July 7th, 2003

Monocyte chemoattractant protein-1 can protect brain cells from HIV-induced apoptosis.

"Acquired immunodeficiency syndrome (AIDS)-associated dementia is often characterized by chronic inflammation, with infected macrophage infiltration of the CNS resulting in the production of human immunodeficiency virus type 1 (HIV-1) products, including tat, and neurotoxins that contribute to neuronal loss," scientists in New York explained.

"In addition to their established role in leukocyte recruitment and activation," E.A. Eugenin and coauthors at Yeshiva University's Albert Einstein College of Medicine in the Bronx "identified an additional role for...

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Source: AIDS Weekly (2003-07-07)

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