Virology

Pirate protein allows infection of resting cells

Published in AIDS Weekly, July 21st, 2003

Even after intense antiviral treatment, HIV-1 can still lurk in inactive cells in the human body, only to reappear at a later date. New research shows how viruses can create these reservoirs and infect inactive T cells.

Three cell types are involved in the process, according to Mario Stevenson and colleagues. First of all, HIV-1 infects a macrophage, causing it to produce a key viral protein, called Nef. The macrophage then releases at least two soluble factors, which stimulate another component of the immune system - nearby B cells. When these cells come into contact with non-cell-cycling T cells, the T cells become susceptible to HIV-1 infection.

...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of AIDS Weekly

Source: AIDS Weekly (2003-07-21)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry