Hepatitis B Therapy

Novel nucleoside analog active against HBV, HIV

Published in AIDS Weekly, July 21st, 2003

A novel agent shows promise for the treatment of both hepatitis B and HIV infection.

According to recent research from the United States, "1-(2,3-Dideoxy-2-fluoro-beta-L-glyceropent-2-enofuranosyl)cytosine (L-2'-Fd4C) is an L-nucleoside analogue with both anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity with median effective concentrations of 0.12 microM in peripheral blood mononuclear cells and 0.002 microM in HepG2-2.2.15 cells, respectively."

R.F. Schinazi and coauthors at the Veterans Affairs Medical Center in Decatur, Georgia conducted a study "to examine the antihepadnavirus potency and pharmacokinetics of...

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Source: AIDS Weekly (2003-07-21)

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