AIDS and HIV Vaccine

Changes in virion internal proteins affect site of lentivirus inactivation

Published in AIDS Weekly, July 21st, 2003

Preferential covalent modification of virion internal proteins affected the sites, mechanism of action, and lack of reversibility of primate lentivirus inactivation.

"By exploiting the intrinsic chemistry of retroviruses, we have developed a novel method for generating whole inactivated virion vaccine immunogens with functional envelope glycoproteins. The method takes advantage of the fact that the internal proteins of retroviruses are adapted to the intracellular (reducing) environment, and have cysteine residues present in thiol-form (S-H), while the surface proteins of retroviruses (the envelope glycoproteins SU and TM) are adapted to the (oxidizing) environment of...

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Source: AIDS Weekly (2003-07-21)

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