HIV/AIDS Therapy

Large number of inexplicable subtherapeutic drug levels observed

Published in AIDS Weekly, July 28th, 2003

A high proportion of HIV patients carry inexplicably low levels of antiretroviral agents.

Researchers in the Netherlands conducted a study "to evaluate plasma concentrations of nonnucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs) within several dosing schemes in a cohort of HIV-infected patients in routine clinical practice and to find possible explanations for subtherapeutic plasma concentrations."

"Patients were included if a PI or NNRTI was part of their antiretroviral regimen, at least one plasma concentration was obtained, and a complete medication overview from community pharmacy records was available," noted...

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Source: AIDS Weekly (2003-07-28)

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