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HIV/AIDS Therapy

Novel inhibitory antibodies isolated

Published in AIDS Weekly, July 28th, 2003

A series of novel anti-HIV antibodies have been identified.

"Inhibitory antibodies to the reverse transcriptase (RT) of human immunodeficiency virus type-1 (HIV-1) can be used to block the life cycle of the virus," researchers in Israel explained.

In their study, A. Herschhorn and coauthors at Tel Aviv University "isolated five different human single chain Fv (ScFv) antibodies specific for HIV-1 RT from an antibody phage display library."

"Three of these antibodies inhibited the RNA-dependent DNA polymerase (RDDP) activity of RT and one of the three (F-6) inhibited also its DNA-dependent DNA polymerase (DDDP) activity," test...

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