HIV/AIDS Immunology
HIV infection impairs B cell costimulatory function
Published in AIDS Weekly, August 4th, 2003
"HIV infection leads to numerous immunologic defects, including impaired B cell function," researchers in the United States explained. "An effective humoral response requires bidirectional interactions between B cells and CD4+ T cells, critical of which are interactions between CD80/CD86 expressed on activated B cells and CD28 expressed on responder CD4+ T cells."
In a recent study, A. Malaspina and coauthors at the National Institute of Allergy and Infectious Diseases "examined the effect of active HIV replication on B cell costimulatory...
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Source: AIDS Weekly (2003-08-04)
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