HIV/AIDS Therapy
HIV protease inhibitors prevent mitochondrial hyperpolarization-induced T-cell apoptosis
Published in AIDS Weekly, August 4th, 2003
"A decrease of mitochondrial membrane potential has been hypothesized to be a marker of apoptotic cells, including activated T lymphocytes," researchers in Italy explained. "It was recently demonstrated that HIV protease inhibitors, independently from any viral infection, can hinder lymphocyte apoptosis by influencing mitochondrial homeostasis."
"To analyze the mechanisms underlying these effects," P. Matarrese and coauthors at the Istituto Superiore di Sanita in Rome examined "resting and activated human PBL [peripheral blood lymphocytes] exposed to...
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Source: AIDS Weekly (2003-08-04)
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