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HIV/AIDS Therapy

Aspirin-like agent suppresses HIV replication

Published in AIDS Weekly, August 4th, 2003

A novel aspirin-like agent strongly suppresses HIV replication in vitro.

"Some anti-inflammatory molecules are also known to possess anti-human immunodeficiency virus (HIV) activity," researchers in the Netherlands noted.

C.F. Pereira and coauthors at the University of Utrecht found that "o-(acetoxyphenyl)hept-2-ynyl sulfide (APHS), a recently synthesized non-steroidal anti-inflammatory molecule, can inhibit HIV-1 replication," and performed a study to "clarify the mechanism of action of APHS."

"When administered during the first steps of the infection, APHS was capable of inhibiting the replication of several HIV-1 strains...

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