Published in AIDS Weekly, August 4th, 2003
"Nucleic acid-based antiviral approaches have been tried against multiple HIV-1 genes with the purpose of downregulating its replication," researchers in India explained. "A unique stem-loop structure called TAR is present at the 5'-end of all HIV-1 transcripts; Tat and other cellular proteins bind to TAR and thus govern transcription."
"Therefore, HIV-1 TAR is an attractive target against which various antiviral approaches could be tried," according to S. Chakraborti and colleagues at the National Institute of Immunology in New Delhi, who "screened several DNA enzymes (Dz's)...
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