HIV/AIDS Obstetrics

Maternal HIV treatment can cause mitochondrial damage in children

Published in AIDS Weekly, August 25th, 2003

Maternal HIV treatment can cause mitochondrial damage in children, although the clinical relevance of this finding is still unclear.

"Although children born to HIV-infected (HIV+) women receiving antiretroviral therapy during pregnancy show virtually no adverse clinical effects at birth, the antiretroviral nucleoside analog drugs are known to damage nuclear and mitochondrial DNA," researchers in the United States explained.

In a study conducted by M.C. Poirier and coauthors at the National Cancer Institute, "biomarkers of mitochondrial toxicity and genotoxicity" were examined "in a well-characterized sample set consisting of infants born to...

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Source: AIDS Weekly (2003-08-25)

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