Immunology

BAFF protects Ig-producing plasmablasts arising from memory B cells

Published in AIDS Weekly, September 8th, 2003

The cytokine BAFF protects immunoglobulin (Ig)-producing plasmablasts arising from memory B cells.

"The generation of Ig-secreting cells (ISCs) from memory B cells requires interactions between antigen-specific (Ag-specific) B cells, T cells, and dendritic cells," scientists in Australia explained. "This process must be strictly regulated to ensure sufficient humoral immunity while avoiding production of pathogenic autoantibodies."

"BAFF, a member of the TNF family, is a key regulator of B cell homeostasis," according to D.T. Avery and colleagues at the Centenary Institute of Cancer Medicine and Cell Biology. "BAFF exerts its effect by binding to...

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Source: AIDS Weekly (2003-09-08)

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