Published in AIDS Weekly, September 15th, 2003
"Infection by HIV-1 causes persistent, long-term high virus production in macrophages," scientists in Italy explained. "Major evidence, both in humans and in primate models, shows the crucial role of macrophages in sustaining virus production and in mediating a cytopathic effect on bystander CD4+ T lymphocytes and neuronal cells."
In their study, E. Garaci and coauthors at the University of Rome 'Tor Vergeta' "used severe combined immunodeficient (SCID) mice engrafted with human peripheral blood lymphocytes (hu-PBL-SCID mice) to investigate the in vivo effect of HIV-1-infected...
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