HIV/AIDS Neurotoxicity
HIV infection impairs astrocyte glutamate transport
Published in AIDS Weekly, September 29th, 2003
"L-Glutamate is the major excitatory neurotransmitter in the brain," researchers in New York explained. "Astrocytes maintain low levels of synaptic glutamate by high-affinity uptake and defects in this function may lead to neuronal cell death by excitotoxicity."
In their study, Z.Y. Wang and colleagues at Columbia University "tested the effects of HIV-1 and its envelope glycoprotein gp120 upon glutamate uptake and expression of glutamate transporters EAAT1 and EAAT2 in fetal human astrocytes in vitro."
"Astrocytes isolated from fetal...
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Source: AIDS Weekly (2003-09-29)
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