HIV/AIDS Immunology
MAPK signaling needed for beta-chemokine production by CD40L-stimulated macrophages
Published in AIDS Weekly, October 13th, 2003
"CD40 ligand is a cell surface molecule on CD4+ T cells that interacts with its receptor, CD40, on antigen presenting cells to mediate humoral and cellular immune responses," scientists in New York explained.
Previous research "demonstrated that a trimeric soluble form of CD40L (CD40LT) activates macrophages to produce beta-chemokines and decrease CCR5 and CD4 cell surface expression, thus inducing resistance to HIV-1 infection," according to P.D. Marzio and coauthors at the North Shore-Long Island Jewish Research Institute in Manhasset. "However, the mechanism(s)...
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Source: AIDS Weekly (2003-10-13)
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