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HIV/AIDS Therapy

Improved method for aryl beta-diketo acids developed

Published in AIDS Weekly, November 3rd, 2003

A novel oxalylation technique may lead to increased production of anti-HIV beta-diketo acids.

According to published study results from China, "An improved and efficient oxalylation of aryl methyl ketones was accomplished with tert-butyl methyl oxalate."

"This is the key step in constructing the pharmacophore of aryl beta-diketo acids, which represent a promising new class of HIV-1 integrase inhibitors," explained X.H. Jiang and coauthors working at the Chinese Academy of Sciences in Shanghai.

"Structurally diverse aryl beta-diketo acids, including bisdiketo acids, can be prepared rapidly in impressive yields under mild conditions...

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