HIV/AIDS Immunology

Exogenous IL-2 improves proliferation of HIV-specific CD4 cells

Published in AIDS Weekly, November 17th, 2003

Low IL-2 production is linked to impaired proliferation of HIV-specific CD4 cells, which can be reversed by treatment with exogenous IL-2.

"Virus-specific CD4+ T-cell function is thought to play a central role in induction and maintenance of effective CD8+ T-cell responses in experimental animals or humans," virologists in the United States noted. "However, the reasons that diminished proliferation of human immunodeficiency virus (HIV)-specific CD4+ T cells is observed in the majority of infected patients and the role of these diminished responses in the loss of control of replication during the chronic phase of HIV infection remain incompletely understood."

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Source: AIDS Weekly (2003-11-17)

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