HIV/AIDS Neurotoxicity
HIV Tat induces cerebral inflammation and monocyte invasion
Published in AIDS Weekly, November 17th, 2003
"Impaired inflammatory functions may be critical factors in the mechanisms by which HIV-1 enters the CNS," scientists in the United States explained. "Evidence indicates that a viral gene product, the protein Tat, can markedly contribute to these effects."
In a recent study, H. Pu and colleagues working at the University of Kentucky Medical Center "tested the hypothesis that Tat can upregulate the expression of inflammatory cytokines and adhesion molecules and facilitate the entry of monocytes into the brain."
"Expression of inflammatory mediators such as...
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Source: AIDS Weekly (2003-11-17)
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