Genomics and Genetics
Genetic recombination between R5 and X4 HIV strains occurs in vivo
Published in AIDS Weekly, November 17th, 2003
"Human immunodeficiency virus type 1 (HIV-1) infection is in general established by CCR5-utilizing (R5) virus variants, which persist throughout the course of infection," scientists in the Netherlands explained. "R5 HIV-1 variants evolve into CXCR4-utilizing (X4) HIV-1 variants in approximately half of the infected individuals."
R.P. van Rij and colleagues at the University of Amsterdam "previously observed an ongoing genetic evolution with a continuous divergence of envelope gp120 sequences of coexisting R5 and X4 virus variants over time."
In a...
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Source: AIDS Weekly (2003-11-17)
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