Drug Development
Easily generated HIV protease inhibitors derived from carbohydrate alditols identified
Published in AIDS Weekly, November 24th, 2003
Scientists in Canada evaluated "the synthesis and structure-activity relationships of HIV protease inhibitors derived from carbohydrate alditols."
"We disclose a new series of 1,2,5,6-tetra-O-alkyl-D-mannitol exhibiting sub-micromolar activity against HIV-protease," according to A. Bouzide and coauthors working at Pharmacor Inc. in Laval.
"This series of inhibitors are non-nitrogen containing HIV-protease inhibitors and they are readily prepared in a few chemical steps from inexpensive commercially available starting materials," the researchers...
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Source: AIDS Weekly (2003-11-24)
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