Published in AIDS Weekly, November 24th, 2003
"The TAR hairpin of the HIV-1 RNA genome is indispensable for transactivation of the viral promoter and virus replication," scientists in Poland explained. "The TAR structure has been studied extensively, but most attention has been directed at the three-nucleotide bulge that constitutes the binding site of the viral Tat protein. In contrast, the conformational properties of the apical loop have remained elusive."
T. Kulinski and colleagues at the Polish Academy of Sciences "performed biochemical studies and molecular dynamics simulations which...
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