HIV/AIDS Gene Therapy
Treatment with multiple small interfering RNAs augments gene silencing
Published in AIDS Weekly, November 24th, 2003
According to scientists in Switzerland, siRNAs "induce gene silencing in various eukaryotic cells, although usually in an incomplete manner."
"Using chemically synthesized siRNAs targeting the HIV-1 co-receptor CXCR4 or the apoptosis-inducing Fas-ligand (FasL), co-transfection of cells with two or more siRNA duplexes targeting different sites on the same mRNA resulted in an enhanced gene silencing compared with each single siRNA," reported J.M. Ji and colleagues at the University of Basel.
"This was shown in the downregulation...
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Source: AIDS Weekly (2003-11-24)
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