Addiction Medicine
High-dose methadone linked to QT prolongation and Torsades de Pointes in HIV patients
Published in AIDS Weekly, December 1st, 2003
According to published research from Spain, "Four patients infected with human immunodeficiency virus receiving antiretroviral treatment and high doses of methadone (>200 mg/day) presented with several syncopal episodes."
"A significant prolongation of the QTc interval was detected in all of them, and in three patients, {{>=}}1 episode of Torsades de Pointes was recorded," M. Gil and coauthors at the Autonomous University of Barcelona reported.
"The sequence of events in these cases suggests that high doses of methadone caused QT...
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Source: AIDS Weekly (2003-12-01)
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