Opportunistic Infections

Lung epithelial cells and matrix components induce P. carinii STE20 expression

Published in AIDS Weekly, December 15th, 2003

Exposure to lung epithelial cells and matrix components triggers expression of the Pneumocystis carinii STE20 gene.

P. carinii "causes severe pneumonia in immunocompromised hosts," scientists in the United States explained. "The binding of P. carinii to alveolar epithelial cells and extracellular matrix constituents such as fibronectin and vitronectin is a central feature of infection, which initiates proliferation of the organism."

In a recent study, T.J. Kottom and colleagues at the Mayo Clinic found that "P. carinii binding to lung cells specifically alters the gene expression of the organism, regulating fungal...

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Source: AIDS Weekly (2003-12-15)

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