Drug Development

HIV RNase H activity characterization leads to novel anti-HIV agents

Published in AIDS Weekly, January 5th, 2004

The activity of HIV RNase H has been elucidated, and this information has been used to develop novel anti-HIV agents

"Human immunodeficiency virus (HIV) RNase H activity is essential for the synthesis of viral DNA by HIV reverse transcriptase (HIV-RT)," scientists in California explained. "RNA cleavage by RNase H requires the presence of divalent metal ions, but the role of metal ions in the mechanism of RNA cleavage has not been resolved."

In their study, K. Klumpp and colleagues working at Roche Palo Alto LLC "measured HIV RNase H activity associated with HIV-RT protein in the presence of different concentrations of either Mg²⁺,...

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Source: AIDS Weekly (2004-01-05)

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