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HIV/AIDS Therapy

Growth hormone treatment can improve NK-cell function

Published in AIDS Weekly, January 5th, 2004

Growth hormone therapy can improve NK-cell function in HIV patients.

"Previous studies have shown that human natural killer (NK) cells are lost from the periphery and are functionally suppressed during HIV-1 infection, and that the administration of highly active antiretroviral therapy (HAART) results in a recovery of NK cell numbers in HIV-1-infected individuals," scientists in England noted. "However, despite this recovery, interleukin (IL)-2 + IL-12-driven interferon (IFN)-gamma production by NK cells has been shown to remain suppressed after HAART."

In their study, M.R. Goodier and coauthors found that "the innate immune factor IL-15 in...

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