Genomics and Genetics

Oxidative DNA damage underlies mitochondrial effects of cancer, HIV drugs

Published in AIDS Weekly, January 19th, 2004

Oxidative damage to nuclear DNA underlies the deleterious effects of cancer and HIV drugs on mitochondria.

"Depletion of the mitochondrial genome is involved in several human diseases, as well as in mitochondrial diseases induced by drug therapies used in the treatment of cancer and human immunodeficiency virus," scientists in New York explained.

"In order to identify the molecular changes underlying the pathogenesis of mitochondrial diseases," R.L. Delsite and colleagues at the Roswell Park Cancer Institute in Buffalo "determined the oxidative status of a human cell line following depletion of the mitochondrial genome (denoted rho⁰...

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Source: AIDS Weekly (2004-01-19)

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