Cell Biology

To avoid detection, HIV disrupts immune cell migration

Published in AIDS Weekly, February 2nd, 2004

The HIV protein Nef sparked intensive research after observations that patients with a rare strain of HIV lacking Nef took a very long time to develop AIDS symptoms. Nef has been linked to molecules involved in cell signaling pathways and may use them for its own ends. But how Nef does this has not been clear.

Now Jacek Skowronski and his colleagues at Cold Spring Harbor Laboratory in New York have identified a mechanism involving Nef by which HIV-infected T cells are kept from traveling to sites within lymphatic tissues where they can become activated.

Skowronski's lab found that Nef associates with two proteins, DOCK2 and ELMO1. DOCK2 regulates...

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Source: AIDS Weekly (2004-02-02)

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