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HIV/AIDS Cancer

Rhesus monkey Rhadinovirus valuable as KSHV model

Published in AIDS Weekly, February 2nd, 2004

Rhesus monkey Rhadinovirus (RRV) can facilitate the study of the virus responsible for Kaposi sarcoma.

According to published research from the United States, RRV "is one of the closest phylogenetic relatives to the human pathogen Kaposi sarcoma-associated herpesvirus (KSHV), yet it has the distinct experimental advantage of entering efficiently into lytic replication and growing to high titers in culture."

"RRV therefore holds promise as a potentially attractive model with which to study gammaherpesvirus structure and assembly," noted C.M. O'Connor and colleagues at the University of Virginia. In a recent study, they "isolated RRV capsids,...

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