HIV/AIDS Immunology

Role of CD40L dysregulation in HIV-related APC impairment reviewed

Published in AIDS Weekly, February 9th, 2004

The role of CD40L dysregulation in HIV-induced impairment of APC function has been reviewed.

"Cellular interactions between antigen-presenting cells and activated CD4+ T cells are central to the regulation of adaptive immunity," immunologists in the United States explained. "Among the many receptor-ligand pairs involved, the critical importance of CD40-CD40 ligand (CD40L) interactions has been demonstrated in many experimental systems."

"Dysregulation of antigen-presenting cell function is a hallmark of HIV-associated defects in cell-mediated immunity," noted C. Chougnet and colleagues at the Cincinnati Children's Hospital. "Much evidence suggests a...

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Source: AIDS Weekly (2004-02-09)

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