HIV/AIDS Therapy
STAT1 blockade shows promise for clearance of latent HIV reservoirs
Published in AIDS Weekly, February 9th, 2004
"Current highly active antiretroviral therapy (HAART) cannot eliminate HIV-1 from infected persons, mainly because of the existence of refractory viral reservoir(s)," scientists in Italy explained.
"Beyond latently-infected CD4+ T lymphocytes, macrophages (M/M) are important persistent reservoirs for HIV in vivo, that represent a major obstacle to HIV-1 eradication," noted M. Magnani and colleagues at the University of Urbino. "Therefore, a rational therapeutic approach directed to the selective elimination of long-living HIV-infected M/M may be...
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Source: AIDS Weekly (2004-02-09)
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