HIV/AIDS Proteomics
Nuclear targeting of HIV Rev transport signals clarified
Published in AIDS Weekly, February 9th, 2004
"The human immunodeficiency Rev protein shuttles between the nucleus and cytoplasm, while accumulating to high levels in the nucleus," scientists in Germany noted. "Rev has a nuclear localization signal (NLS; AA 35-50) with an arginine-rich motif (ARM) that interacts with importin beta and a leucine-rich nuclear export signal (NES; AA 75-84) recognized by CRM1/exportin 1."
In a recent study, S. Demart and colleauges at the National Research Center for Environment and Health (GSF) in Neuherberg examined the "nuclear targeting activities of the transport signals of...
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Source: AIDS Weekly (2004-02-09)
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