HIV/AIDS Pathogenesis
Serum SDF-1 inactivated during HIV infection
Published in AIDS Weekly, February 9th, 2004
"The chemokine stromal-derived factor-1 (SDF-1) can block human immunodeficiency virus type I (HIV-1) infection in vitro by binding to the CXC chemokine receptor, CXCR-4, which serves as a coreceptor for T-cell tropic HIV-1," immunologists in the United States explained. "In spite of being constitutively expressed in vivo, SDF-1 does not appear to block HIV-1 infection and spread in vivo."
SDF-1 "is consistently measured in normal serum (15.4±3.0 ng/mL; mean±SD) and in serum from AIDS patients (16.6±3.7 ng/mL)," noted S. Villalba and colleagues at the National Cancer Institute....
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Source: AIDS Weekly (2004-02-09)
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