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HIV/AIDS Therapy

Tenofovir DF pharmacokinetics similar in children and adults

Published in AIDS Weekly, February 16th, 2004

The pharmacokinetics of tenofovir disoproxil fumarate (DF) are similar in pediatric and adult HIV patients.

Tenofovir DF "is a potent nucleotide analog reverse transcriptase inhibitor approved for the treatment of human immunodeficiency virus (HIV)-infected adults," scientists in the United States explained.

In a study conducted by R. Hazra and colleagues at the U.S. National Cancer Institute, "the single-dose and steady-state pharmacokinetics of tenofovir were evaluated following administration of tenofovir DF in treatment-experienced HIV-infected children requiring a change in antiretroviral therapy."

"Using increments of...

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