HIV/AIDS Vaccine

Broadly cross-reactive HIV-neutralizing antibody Fab identified

Published in AIDS Weekly, February 16th, 2004

Researchers have identified a broadly cross-reactive HIV-neutralizing human monoclonal antibody Fab by sequential antigen panning of a phage display library.

"Identification of broadly cross-reactive human monoclonal antibodies (mAbs) has major implications for development of vaccines, inhibitors, and research tools. Here we describe a sequential antigen panning (SAP) methodology that may facilitate the selection of such antibodies. An HIV-specific antibody Fab (m18) was selected from a human Fab phage-display library by SAP against several recombinant soluble HIV envelope glycoproteins (Envs) and Env-sCD4 complexes," scientists in the United States report.

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Source: AIDS Weekly (2004-02-16)

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