Published in AIDS Weekly, February 23rd, 2004
According to a study from Sweden, "infection with Kaposi sarcoma-associated herpesvirus (KSHV) is a prerequisite for Kaposi sarcoma, a multicentric endothelial tumor of mixed blood vessel-lymphatic phenotype with a marked production of endothelial basement membrane proteins. The viral K1 gene encodes a unique transmembrane protein capable of transforming T lymphocytes experimentally. We studied the effects of K1 regulated by the endothelium-specific tie-1 promoter in the embryonic stem cell (ES)-derived endothelium of subcutaneous murine teratomas and in embryoid body cultures with and...
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