HIV/AIDS Pathogenesis

HIV nuclear entry does not require mitosis in cycling cells

Published in AIDS Weekly, February 23rd, 2004

HIV nuclear entry is mitosis-independent in cycling cells.

"An essential step in human immunodeficiency virus type 1 (HIV-1) replication is the movement of the viral preintegration complex from the cytoplasm into the nucleus," virologists in the United States explained. However, the "pathway(s) and timing for HIV-1 DNA nuclear entry in cycling cells have not been established."

In their study, R.A. Katz and colleagues at the University of Pennsylvania found that, "if cycling cells are infected before S phase, viral DNA can be integrated prior to passage of the host DNA replication fork through the integration site, as indicated by stable inheritance...

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Source: AIDS Weekly (2004-02-23)

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