HIV/AIDS Dementia
CXCR4 mediates gp120 neurotoxicity in cerebellar granule cells
Published in AIDS Weekly, March 1st, 2004
"The human immunodeficiency virus type 1 (HIV-1) glycoprotein gp120 causes neuronal cell death; however, the molecular mechanisms of the neurotoxic effect remain largely unresolved," neurologists in the United States explained. "It has been suggested that gp120 evokes cell death by inducing the release of neurotoxins, including glutamate."
In their study, A. Bachis and colleagues at Georgetown University investigated "the role of glutamate in gp120-mediated neurotoxicity."
"We used as an experimental tool cerebellar granule cells prepared from 8-day-old...
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Source: AIDS Weekly (2004-03-01)
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