Published in AIDS Weekly, March 1st, 2004
According to recent research from Portugal, "Partition of the intrinsically fluorescent HIV fusion inhibitor enfuvirtide into lipidic membranes is relatively high (DeltaG=6.6 kcal/mol) and modulated by cholesterol."
"A shallow position in the lipidic matrix makes it readily available for interaction with gp41," reported S. Veiga and coauthors at the University of Lisbon. "No conformational energetic barrier prevents enfuvirtide from being active in both aqueous solution and lipidic membranes."
"Lipidic membranes may play a key role in the...
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