HIV/AIDS Pathogenesis

Immune failure occurs without CD4+ T-cell depletion in SIV-infected macaques

Published in AIDS Weekly, March 8th, 2004

Immune failure occurs in the absence of profound CD4+ T-lymphocyte depletion in simian immunodeficiency virus-infected rapid progressor macaques

According to recent research published in the Journal of Virology, "A fraction of simian immunodeficiency virus (SIV)-infected macaques develop rapidly progressive disease in the apparent absence of detectable SIV-specific antibody responses. To characterize the immunopathogenesis of this syndrome, we studied viral load, CD4+ T-lymphocyte numbers as well as cellular and humoral immune responses to SIV and other exogenous antigens in four SIVsm-infected rhesus macaques that progressed to AIDS 9 to 16 weeks...

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Source: AIDS Weekly (2004-03-08)

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