Parasitology

Discovery could lead to better treatment for cryptosporidum infections

Published in AIDS Weekly, March 8th, 2004

In 1993, a water-borne parasite in Milwaukee was responsible for an estimated 403,000 cases of acute gastrointestinal disease, and the outbreak revealed that patients with AIDS are at an especially grave risk.

About half of Milwaukee's residents with AIDS were infected with the parasite, 68% of whom died within 6 months. This parasite, Cryptosporidium parvum, is highly resistant to standard water treatment, which has caused additional concerns over its potential use in bioterrorism.

Now a team of biologists from the University of Georgia (UGA), led by Boris Striepen, has discovered that the parasite depends on so-called "salvage enzymes" to...

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Source: AIDS Weekly (2004-03-08)

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