HIV/AIDS Dementia

HIV Tat induces XCL1 expression by lymphocytes

Published in AIDS Weekly, March 15th, 2004

HIV Tat induces XCL1 expression by lymphocytes, and these XCL1-expressing cells appear to play a key role in the pathogenesis of HIV-associated dementia.

According to recent research from the United States, "HIV-1 Tat has been proposed as a key agent in many AIDS-related disorders, including HIV-1-associated neurological diseases."

"The CNS infiltration of T lymphocytes has been noted in AIDS patients," noted B.O. Kim and colleagues at Indiana University, who previously found that "Tat expression induces a significant increase in T lymphocytes in the brains of Tat transgenic mice."

Using "this unique genetic system," the...

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Source: AIDS Weekly (2004-03-15)

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