Drug Development
Antiretroviral DCK analogues synthesized
Published in AIDS Weekly, March 15th, 2004
"To enhance the water solubility and oral bioavailability of DCK analogues, 12 new mono- and disubstituted (3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) analogues were synthesized and evaluated for inhibition of HIV-1 replication in H9 lymphocytes," in a recent study from the United States.
According to L. Xie and coauthors at the University of North Carolina, "3-hydroxymethyl-4-methyl-DCK (4c) exhibited significant anti-HIV activity in H9 lymphocytes and primary peripheral blood mononuclear cells with EC50 values of 0.004 and 0.024 microM, respectively."
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Source: AIDS Weekly (2004-03-15)
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