Published in AIDS Weekly, March 22nd, 2004
According to recent research from Italy, the "binding properties of a set of four hybrids, prepared combining from one to four polypyrrole minor groove binders and pyrrolo[2,1-c][1,4]benzodiazepine (PBD), have been studied using as target molecule the HIV-1 TAR-RNA."
C. Mischiati and coauthors at the University of Ferrara found that "these hybrids bind to TAR-RNA and inhibit TAR/protein(s) interactions."
"The anti-proliferative activity of the hybrids has been tested in vitro on HL3T1 cells and compared to the anti-proliferative effects of the natural...
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