HIV/AIDS RNA Studies
Antisense oligonucleotide scanning arrays reveal novel HIV leader RNA foldings
Published in AIDS Weekly, March 29th, 2004
According to recent research from the Netherlands, "[s]canning arrays of antisense DNA oligonucleotides provide a novel and systematic means to study structural features within an RNA molecule."
M. Ooms and coauthors at the University of Amsterdam "used this approach to probe the structure of the untranslated leader of the human immunodeficiency virus type 1 (HIV-1) RNA genome."
"This 335 nt RNA encodes multiple important replication signals and adopts two mutually exclusive conformations," they wrote in the...
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Source: AIDS Weekly (2004-03-29)
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