Published in AIDS Weekly, April 19th, 2004
"The linear peptide 12p1 (RINNIPWSEAMM) was previously isolated from a phage display library and was found to inhibit interaction of HIV-1 gp120 with both CD4 and a CCR5 surrogate, mAb 17b [Ferrer, M, and Harrison, S. (1999) J. Virol. 73, 5795-5802]," scientists in Philadelphia explained.
In their study, A.C. Biorn and colleagues at Drexel University "investigated the mechanism that leads to this dual inhibition of gp120 binding."
The collaborators discovered "a direct interaction of 12p1 with gp120, which occurs with a binding stoichiometry of 1:1,"...
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