Drug Development
Anti-HIV activity of linear peptide gp120 inhibitors characterized
Published in AIDS Weekly, April 19th, 2004
"The linear peptide 12p1 (RINNIPWSEAMM) was previously isolated from a phage display library and was found to inhibit interaction of HIV-1 gp120 with both CD4 and a CCR5 surrogate, mAb 17b [Ferrer, M, and Harrison, S. (1999) J. Virol. 73, 5795-5802]," scientists in Philadelphia explained.
In their study, A.C. Biorn and colleagues at Drexel University "investigated the mechanism that leads to this dual inhibition of gp120 binding."
The collaborators discovered "a direct interaction of 12p1 with gp120, which occurs with a binding stoichiometry of 1:1,"...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of AIDS Weekly
Source: AIDS Weekly (2004-04-19)
More Articles from AIDS Weekly
- Drug Development
Lipophilic substitutions improve benzylpyrazole CCR5 antagonists - HIV/AIDS Protein Research
Chimeric HIV/SIV provides stable trimeric HIV Env for study - HIV/AIDS Immune Control
IL-15 levels elevated in patients with discordant response to treatment - HIV/AIDS Immune Control
Scavenger function of CCR5Delta32 protein involved in protection from HIV - HIV/AIDS Therapy
MALDI-TOF MS assay provides improved NRTI monitoring - AIDS
NIH grant to be used to develop novel anti-HIV therapeutics - More from this issue of AIDS Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
