HIV/AIDS Enzymology
Intracellular transport of HIV integrase elucidated
Published in AIDS Weekly, April 26th, 2004
"The human immunodeficiency virus type 1 integrase protein has karyophilic properties; that is, it localizes to the cell nucleus according to a range of assays," scientists in the United States explained. "As an essential component of the preintegration complex, it has been suggested that the karyophilic properties of integrase might facilitate transport of the preintegration complex through the nuclear pore complexes of nondividing cells.
"However, no experiments have satisfactorily identified a nuclear localization signal within integrase," noted E. Devroe and colleagues at Harvard...
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Source: AIDS Weekly (2004-04-26)
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