HIV/AIDS Therapy
Anti-NeoR6 resistance mutations suggest anti-HIV mechanisms
Published in AIDS Weekly, April 26th, 2004
"Aminoglycoside-arginine conjugates (AACs) inhibit HIV-1 replication and act as Tat antagonists," scientists in Israel explained. "AACs compete with monoclonal antibody binding to CXCR4" and with "SDF-1alpha and HIV-1 gp120 cellular uptake, indicating that they interfere with initial steps of HIV-1 infection."
G. Borkow and colleagues working at the Weizmann Institute of Science in Rehovot described "the selection of HIV-1 isolates resistant to hexa-arginine neomycin B conjugate (NeoR6), the most potent anti-HIV-1 AAC."
...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of AIDS Weekly
Source: AIDS Weekly (2004-04-26)
More Articles from AIDS Weekly
- Drug Development
Lavendamycin analogues show promise as HIV reverse transcriptase inhibitors - Drug Development
Plant-derived liminoids exhibit potent antiretroviral activity - HIV/AIDS Enzymology
Intracellular transport of HIV integrase elucidated - HIV/AIDS Proteomics
Nuclear targeting activities of HIV Rev transport signals characterized - AIDS/HIV Vaccine
Finding epitopes of HIV-1 that induce protective antibodies remains a challenge - AIDS/HIV Vaccine
MVA-HIV-1 nef vaccine elicits T-helper cell responses in HIV patients - More from this issue of AIDS Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
