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AIDS/HIV Vaccine

Finding epitopes of HIV-1 that induce protective antibodies remains a challenge

Published in AIDS Weekly, April 26th, 2004

Identifying epitopes of HIV-1 that induce protective antibodies remains a challenge.

According to recent research published in the journal Nature Reviews Immunology, "During the past 20 years, the pendulum of opinion in the HIV-1 vaccine field has swung between two extremes, initially favoring the induction of antibodies only, and subsequently favoring the induction of cell-mediated immune responses only. At present, the consensus seems to be that induction of both humoral and cellular immunity by an HIV-1 vaccine will be required to achieve maximum protection.

"One obstacle to the development of an effective HIV-1 vaccine has been the...

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