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AIDS/HIV Vaccine

Components of HIV vaccine are recognized by T-helper cells

Published in AIDS Weekly, May 17th, 2004

Minor components of a multi-envelope HIV vaccine are recognized by type-specific T-helper cells.

"HIV has thus far evaded control by vaccines, in part due to the high diversity among viral isolates. To effectively target HIV diversity, we propose that multi-envelope HIV vaccines should be designed. We hypothesize that minor components of complex envelope cocktail vaccines can be immunogenic and can thus elicit unique T-cell responses," researchers in the United States report.

"To test our hypothesis, we first defined unique T-helper cell determinants on 1007 (clade B) and UG92005 (UG, clade D) gp140 envelope proteins delivered by DNA vaccination,"...

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